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Article

Direct contact with natural killer cells reprograms monocyte-derived dendritic cells into a tolerogenic phenotype.

ImmunoHorizons - 10 Mar 2026

Alsheikh Ammar J, Chen Liang, Korenfeld Daniel, Tam Jason, Patil Suresh, Wei Hsi-Ju, Li Jianing, Zhong Suju, Dong Feng, Melim Terry, Orsi Karin, Karsen Samuel, Yang Yingli, Westmoreland Susan, Pandit Aridaman, White Kevin, Radstake Timothy, Suarez-Fueyo Abel

Abstract excerpt

Tissue-infiltrating monocyte-derived dendritic cells (DCs) and macrophages are key antigen-presenting cells promoting inflammation and tissue damage by releasing proinflammatory cytokines and strongly activating T cells. These antigen-presenting cells are prominent in inflamed tissues, including in conditions such as inflammatory bowel disease. Modulating the number or function of these cells presents an...

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Identifiers

PMID: 41886078
DOI: 10.1093/immhor/vlag007
PMCID: PMC13020354

Genes

CD40
CD44
IDO1
IKZF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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