Article

CRISPR-based functional genomics in human dendritic cells

2020-12-22

Abstract excerpt

Dendritic cells (DCs) regulate processes ranging from antitumor and antiviral immunity to host-microbe communication at mucosal surfaces. It remains difficult, however, to genetically manipulate human DCs, limiting our ability to probe how DCs elicit specific immune responses. Here, we develop a CRISPR/Cas9 genome editing method for human monocyte-derived DCs (moDCs) that mediates knockouts with a median efficienc...

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Literature Corpus work: 1563d42b-a888-590d-9118-d0ab22f0eed1
DOI: 10.1101/2020.12.22.423985

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