Article
CCR2(+)CD103(-) intestinal dendritic cells develop from DC-committed precursors and induce interleukin-17 production by T cells.
Mucosal immunology - 1 Mar 2015
Scott C L, Bain C C, Wright P B, Sichien D, Kotarsky K, Persson E K, Luda K, Guilliams M, Lambrecht B N, Agace W W, Milling S Wf, Mowat A M
Abstract excerpt
The identification of intestinal macrophages (mφs) and dendritic cells (DCs) is a matter of intense debate. Although CD103(+) mononuclear phagocytes (MPs) appear to be genuine DCs, the nature and origins of CD103(-) MPs remain controversial. We show here that intestinal CD103(-)CD11b(+) MPs can be separated clearly into DCs and mφs based on phenotype, gene profile, and kinetics. CD64(-)CD103(-)CD11b(+) MPs are...
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