Article
Intestinal Antigen-Presenting Cells: Key Regulators of Immune Homeostasis and Inflammation.
The American journal of pathology - 1 Jul 2015
Flannigan Kyle L, Geem Duke, Harusato Akihito, Denning Timothy L
Abstract excerpt
The microbiota that populate the mammalian intestine are critical for proper host physiology, yet simultaneously pose a potential danger. Intestinal antigen-presenting cells, namely macrophages and dendritic cells (DCs), are integral components of the mucosal innate immune system that maintain co-existence with the microbiota in face of this constant threat. Intestinal macrophages and DCs integrate signals from...
Topics
- Animals
- Antigen-Presenting Cells
- Awards and Prizes
- Dendritic Cells
- Homeostasis
- Humans
- Immune Tolerance
- Inflammation
- Intestines
- Macrophages
- Mammals
- Microbiota