MEF2C-MYOCD and Leiomodin1 Suppression by miRNA-214 Promotes Smooth Muscle Cell Phenotype Switching in Pulmonary Arterial Hypertension.

doi:10.1371/journal.pone.0153780

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Article

MEF2C-MYOCD and Leiomodin1 Suppression by miRNA-214 Promotes Smooth Muscle Cell Phenotype Switching in Pulmonary Arterial Hypertension.

PloS one - 1 Jan 2016

Sahoo Sanghamitra, Meijles Daniel N, Al Ghouleh Imad, Tandon Manuj, Cifuentes-Pagano Eugenia, Sembrat John, Rojas Mauricio, Goncharova Elena, Pagano Patrick J

Abstract excerpt

BACKGROUND: Vascular hyperproliferative disorders are characterized by excessive smooth muscle cell (SMC) proliferation leading to vessel remodeling and occlusion. In pulmonary arterial hypertension (PAH), SMC phenotype switching from a terminally differentiated contractile to synthetic state is gaining traction as our understanding of the disease progression improves. While maintenance of SMC contractile...

Topics

Antagomirs
Autoantigens
Cell Differentiation
Cell Line
Cell Proliferation
Cytoskeletal Proteins
Down-Regulation
Familial Primary Pulmonary Hypertension
HEK293 Cells
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hypertension, Pulmonary

MEF2 Transcription Factors

MicroRNAs

Muscle Contraction

Muscle, Smooth, Vascular

Myocytes, Smooth Muscle

Nuclear Proteins

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 27144530
DOI: 10.1371/journal.pone.0153780
PMCID: PMC4856285

Genes

MYOCD
PAH
LMOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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