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Article

MEF2C-MYOCD and Leiomodin1 Suppression by miRNA-214 Promotes Smooth Muscle Cell Phenotype Switching in Pulmonary Arterial Hypertension.

PloS one - 1 Jan 2016

Sahoo Sanghamitra, Meijles Daniel N, Al Ghouleh Imad, Tandon Manuj, Cifuentes-Pagano Eugenia, Sembrat John, Rojas Mauricio, Goncharova Elena, Pagano Patrick J

Abstract excerpt

BACKGROUND: Vascular hyperproliferative disorders are characterized by excessive smooth muscle cell (SMC) proliferation leading to vessel remodeling and occlusion. In pulmonary arterial hypertension (PAH), SMC phenotype switching from a terminally differentiated contractile to synthetic state is gaining traction as our understanding of the disease progression improves. While maintenance of SMC contractile...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Muscle, Smooth, Vascular

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Source

Open in PubMed Open full text

Identifiers

PMID: 27144530
DOI: 10.1371/journal.pone.0153780
PMCID: PMC4856285

Genes

MYOCD
PAH
LMOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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