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The clinical impact of artemisinin resistance in Southeast Asia and the potential for future spread.

FEMS microbiology reviews - 1 Jan 2017

Woodrow Charles J, White Nicholas J

Abstract excerpt

Artemisinins are the most rapidly acting of currently available antimalarial drugs. Artesunate has become the treatment of choice for severe malaria, and artemisinin-based combination therapies (ACTs) are the foundation of modern falciparum malaria treatment globally. Their safety and tolerability profile is excellent. Unfortunately, Plasmodium falciparum infections with mutations in the 'K13' gene, with reduced...

Topics

Antimalarials
Artemisinins
Asia, Southeastern
Drug Resistance
Forecasting
Humans
Malaria, Falciparum
Mutation
Plasmodium falciparum

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 27613271
DOI: 10.1093/femsre/fuw037
PMCID: PMC5424521

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