Article

Functional validation of the <i>Plasmodium falciparum</i> K13 C580Y mutation in recently collected Ethiopian isolates

2026-03-17

Abstract excerpt

Recent genomic investigation in Ethiopia identified the first detection of the Plasmodium falciparum kelch13 (K13) C580Y substitution in the Horn of Africa. To assess its functional impact, we introduced C580Y into two recently collected Ethiopian clinical isolates using CRISPR-Cas9 genome editing. Ring-stage survival assays showed significantly elevated in vitro dihydroartemisinin (DHA) survival in edited parasi...

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Literature Corpus work: 7941625a-c2b5-50b2-b04c-f8475a3abd12
DOI: 10.64898/2026.03.17.712112

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