Article
Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in Southeast Asia.
The Journal of infectious diseases - 1 Mar 2015
Takala-Harrison Shannon, Jacob Christopher G, Arze Cesar, Cummings Michael P, Silva Joana C, Dondorp Arjen M, Fukuda Mark M, Hien Tran Tinh, Mayxay Mayfong, Noedl Harald, Nosten Francois, Kyaw Myat P, Nhien Nguyen Thanh Thuy, Imwong Mallika, Bethell Delia, Se Youry, Lon Chanthap, Tyner Stuart D, Saunders David L, Ariey Frederic, Mercereau-Puijalon Odile, Menard Didier, Newton Paul N, Khanthavong Maniphone, Hongvanthong Bouasy, Starzengruber Peter, Fuehrer Hans-Peter, Swoboda Paul, Khan Wasif A, Phyo Aung Pyae, Nyunt Myaing M, Nyunt Myat H, Brown Tyler S, Adams Matthew, Pepin Christopher S, Bailey Jason, Tan John C, Ferdig Michael T, Clark Taane G, Miotto Olivo, MacInnis Bronwyn, Kwiatkowski Dominic P, White Nicholas J, Ringwald Pascal, Plowe Christopher V
Abstract excerpt
BACKGROUND: The emergence of artemisinin-resistant Plasmodium falciparum in Southeast Asia threatens malaria treatment efficacy. Mutations in a kelch protein encoded on P. falciparum chromosome 13 (K13) have been associated with resistance in vitro and in field samples from Cambodia. METHODS: P. falciparum infections from artesunate efficacy trials in Bangladesh, Cambodia, Laos, Myanmar, and Vietnam were...
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