Article

PINK1/Parkin-dependent mitophagy mediates astrocytic inflammatory responses to mitochondrial damage

2026-05-13

Abstract excerpt

<h4>ABSTRACT</h4> Astrocytes directly influence neuronal survival and increasingly are understood to contribute to the progression of neurodegenerative diseases including Parkinson’s disease (PD). Mitochondrial damage is a hallmark of PD pathology in both neurons and astrocytes. Damaged mitochondria are cleared by PINK1/Parkin-mediated mitophagy; loss-of-function mutations in either PINK1 or Parkin are sufficient...

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Literature Corpus work: 07fa06f8-ce54-50da-8b45-1240607fa35e
DOI: 10.64898/2026.05.11.724378

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