Article

Connecting gene regulatory relationships to neurobiological mechanisms of brain disorders

2019-06-24

Abstract excerpt

Despite being clinically distinguishable, many neuropsychiatric disorders display a remarked level of genetic correlation and overlapping symptoms. Deciphering neurobiological mechanisms underlying potential shared genetic etiology is challenging because (1) most common risk variants reside in the non-coding region of the genome, and (2) a genome-wide framework is required to compare genome-wide association studie...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4563276d-abdb-54e5-a3bd-21ab0946eb31
DOI: 10.1101/681353

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Connecting gene regulatory relationships to neurobiological mechanisms of brain disordersDOI 10.1101/681353Read

A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles.Semantic proximity Read

The shared genetic risk architecture of neurological and psychiatric disorders: a genome-wide analysisSemantic proximity Read

Accurate identification of genes associated with brain disorders by integrating heterogeneous genomic data into a Bayesian framework.Semantic proximity Read

Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease.Semantic proximity Read

From variants to mechanisms: Neurogenomics in the post-GWAS era.Semantic proximity Read

Genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathwaysSemantic proximity Read

scGRNom: a computational pipeline of integrative multi-omics analyses for predicting cell-type disease genes and regulatory networksSemantic proximity Read

Functional genomics links genetic origins to pathophysiology in neurodegenerative and neuropsychiatric disease.Semantic proximity Read

The road to precision psychiatry: translating genetics into disease mechanisms.Semantic proximity Read

Developmental expression of risk genes implicates the age of onset for neuropsychiatric disordersSemantic proximity Read

Spatiotemporal brain transcriptomics reveal risk gene hot-spots in major neuropsychiatric disorders.Semantic proximity Read

Cell-type-specific genetic architecture reveals neuronal and immune contributions to neuropsychiatric disorders.Semantic proximity Read