Long non-coding RNA CARDINAL cis-activates MYOCD expression by recruiting histone reader ZZZ3 in vascular smooth muscle cell phenotype alteration.

doi:10.1093/cvr/cvag157

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Article

Long non-coding RNA CARDINAL cis-activates MYOCD expression by recruiting histone reader ZZZ3 in vascular smooth muscle cell phenotype alteration.

Cardiovascular research - 26 Aug 2026

Zhou Huimin, Zhang Shaozhao, Xu Xingfeng, Huang Yiquan, Zhang Dihua, Xie Peihan, Li Kang, Lin Yifen, Yang Tiqun, Du Tailai, Wu Jialing, Yan Youchen, Xu Ting, Li Miaohong, Xiong Zhenyu, Guo Yue, Ou Jingsong, Zhuang Xiaodong, Huang Zhan-Peng, Liao Xinxue

Abstract excerpt

AIMS: The phenotype alteration of vascular smooth muscle cells (VSMCs) is critical for vascular physiology and pathology. Transcription factors (TFs) and long non-coding RNAs (lncRNAs) play pivotal roles in the gene regulatory network underlying various biological processes, including the pathogenesis of vascular diseases. Despite the established role of Myocardin (MYOCD) as a master TF in VSMC biology, the...

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