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Single-cell RNA sequencing reveals that NRF2 regulates vascular smooth muscle cell phenotypic switching in abdominal aortic aneurysm.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 15 Jul 2024

Xiao Xiaoyong, Li Chenglin, Huang Xiaojia, Chen Guona, Huang Xiaoran, Song Feier, Zhou Yu, Liu Xincheng, Zhou Xueke, Meng Jinxiu, Bellou Abdelouahab, Zhong Lintao, Li Xin

Abstract excerpt

Abdominal aortic aneurysm (AAA) is a life-threatening disease characterized by extensive membrane destruction in the vascular wall that is closely associated with vascular smooth muscle cell (VSMC) phenotypic switching. A thorough understanding of the changes in regulatory factors during VSMC phenotypic switching is essential for managing AAA therapy. In this study, we revealed the impact of NRF2 on the...

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Share to Angiotensin II
Share to Aortic Aneurysm, Abdominal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MicroRNAs

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to NF-E2-Related Factor 2

Share to Sequence Analysis, RNA

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Identifiers

PMID: 38995239
DOI: 10.1096/fj.202400001RR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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