Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Higher eQTL power reveals signals that boost GWAS colocalization.

American journal of human genetics - 2 Apr 2026

Rosen Jonathan D, Broadaway K Alaine, Brotman Sarah M, Mohlke Karen L, Love Michael I

Abstract excerpt

Expression quantitative trait locus (eQTL) studies in human cohorts typically detect at least one regulatory signal per gene and have been proposed as a way to explain mechanisms of genetic liability for other traits, as discovered in genome-wide association studies (GWASs). In particular, eQTL signals may colocalize with GWAS signals, suggesting gene expression as a possible mediator. However, recent studies...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Share to Sample Size

Source

Open in PubMed Open full text

Identifiers

PMID: 41785861
DOI: 10.1016/j.ajhg.2026.02.009
PMCID: PMC13059134

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Higher eQTL power reveals signals that boost GWAS colocalization.PMID 41785861Read ↗

Higher eQTL power reveals signals that boost GWAS colocalizationSemantic proximity Read ↗

Probabilistic Colocalization of Genetic Variants from Complex and Molecular Traits: Promise and LimitationsSemantic proximity Read ↗

Probabilistic colocalization of genetic variants from complex and molecular traits: promise and limitations.Semantic proximity Read ↗

Transcriptome-wide association studies accounting for colocalization using Egger regressionSemantic proximity Read ↗

Design and interpretation of eQTL-GWAS colocalisation studies: Lessons from a large-scale evaluation.Semantic proximity Read ↗

Transcriptome-wide association studies accounting for colocalization using Egger regression.Semantic proximity Read ↗

Colocalization of GWAS and eQTL Signals Detects Target GenesSemantic proximity Read ↗

A powerful and versatile colocalization test.Semantic proximity Read ↗

Analyzing and reconciling colocalization and transcriptome-wide association studies from the perspective of inferential reproducibility.Semantic proximity Read ↗

Integration of genetic colocalizations with physiological and pharmacological perturbations identifies cardiometabolic disease genesSemantic proximity Read ↗

Extensive co-regulation of neighboring genes complicates the use of eQTLs in target gene prioritization.Semantic proximity Read ↗

Identification of putative effector genes across the GWAS Catalog using molecular quantitative trait loci from 68 tissues and cell typesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.