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Article

A powerful and versatile colocalization test.

PLoS computational biology - 1 Apr 2020

Deng Yangqing, Pan Wei

Abstract excerpt

Transcriptome-wide association studies (TWAS and PrediXcan) have been increasingly applied to detect associations between genetically predicted gene expressions and GWAS traits, which may suggest, however do not completely determine, causal genes for GWAS traits, due to the likely violation of their imposed strong assumptions for causal inference. Testing colocalization moves it closer to establishing causal...

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Share to Computational Biology
Share to Gene Expression Profiling
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 32275709
DOI: 10.1371/journal.pcbi.1007778
PMCID: PMC7176287

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