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Article

Transcriptome-wide association studies accounting for colocalization using Egger regression.

Genetic epidemiology - 1 Jul 2018

Barfield Richard, Feng Helian, Gusev Alexander, Wu Lang, Zheng Wei, Pasaniuc Bogdan, Kraft Peter

Abstract excerpt

Integrating genome-wide association (GWAS) and expression quantitative trait locus (eQTL) data into transcriptome-wide association studies (TWAS) based on predicted expression can boost power to detect novel disease loci or pinpoint the susceptibility gene at a known disease locus. However, it is often the case that multiple eQTL genes colocalize at disease loci, making the identification of the true...

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Identifiers

PMID: 29808603
DOI: 10.1002/gepi.22131
PMCID: PMC6342197

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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