Article

Higher eQTL power reveals signals that boost GWAS colocalization

2025-08-05

Abstract excerpt

Expression quantitative trait locus (eQTL) studies in human cohorts typically detect at least one regulatory signal per gene, and have been proposed as a way to explain mechanisms of genetic liability for other traits, as discovered in genome-wide association studies (GWAS). In particular, eQTL signals may colocalize with GWAS signals, suggesting gene expression as a possible mediator. However, recent studies have...

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Literature Corpus work: a06c73cd-7b58-559a-871e-f635aadf28ba
DOI: 10.1101/2025.08.05.668745

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