Analyzing and reconciling colocalization and transcriptome-wide association studies from the perspective of inferential reproducibility.

Abstract excerpt

Transcriptome-wide association studies and colocalization analysis are popular computational approaches for integrating genetic-association data from molecular and complex traits. They show the unique ability to go beyond variant-level genetic-association evidence and implicate critical functional units, e.g., genes, in disease etiology. However, in practice, when the two approaches are applied to the same...

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