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Article

Evidence for dual roles of histone H3 lysine 4 in antagonizing Polycomb group function and promoting target gene expression.

Genes & development - 27 Nov 2024

Anyetei-Anum Cyril S, Leatham-Jensen Mary P, Fox Geoffrey C, Smith B Rutledge, Chirasani Venkat R, Krajewski Krzysztof, Strahl Brian D, Dowen Jill M, Matera A Gregory, Duronio Robert J, McKay Daniel J

Abstract excerpt

Tight control over cell identity gene expression is necessary for proper adult form and function. The opposing activities of Polycomb and trithorax complexes determine the on/off state of cell identity genes such as the Hox factors. Polycomb group complexes repress target genes, whereas trithorax group complexes are required for their expression. Although trithorax and its orthologs function as methyltransferases...

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PMID: 39562140
DOI: 10.1101/gad.352181.124
PMCID: PMC11610931

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Evidence for dual roles of histone H3 lysine 4 in antagonizing Polycomb group function and promoting target gene expression.PMID 39562140Read ↗

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