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Article

Mutant p53 epigenetically rewires CXCL10 to promote CD8⁺ T-cell infiltration and enhance the anti-PD-1 response in advanced prostate cancer.

Journal of experimental & clinical cancer research : CR - 3 Mar 2026

Chen Jia, Ge Qintao, He Jun, Bian Zichen, Yu Haoming, Li Chun, Meng Jialin, Yin Shuiping, Hao Zongyao, Liang Chaozhao, Zhang Meng

Abstract excerpt

BACKGROUND: TP53 mutations are frequently linked to an immunosuppressive tumor microenvironment and resistance to immune checkpoint blockade (ICB). However, their mechanistic role in shaping antitumor immunity in advanced prostate cancer remains unclear. METHODS: We generated CRISPR-Cas9-engineered murine prostate cancer models harboring the Trp53 p.R245Q knock-in mutation (orthologous to human TP53 p.R248Q)....

Read the complete abstract on PubMed

Topics

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Share to CD8-Positive T-Lymphocytes
Share to Chemokine CXCL10

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Immune Checkpoint Inhibitors

Share to Lymphocytes, Tumor-Infiltrating

Share to Programmed Cell Death 1 Receptor

Share to Prostatic Neoplasms

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 41776659
DOI: 10.1186/s13046-026-03672-z
PMCID: PMC13003701

Genes

CXCL10
TP53
CXCR3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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