Article
A cellular and spatial atlas of TP53-associated tissue remodeling defines a multicellular tumor ecosystem in lung adenocarcinoma.
Nature cancer - 1 Nov 2025
Zhao William, Nguyen Thinh T, Bhagwat Atharva, Kumar Akhil, Giotti Bruno, Kepecs Benjamin, Weirather Jason L, Mahadevan Navin R, Segerstolpe Asa, Dolasia Komal, Abdul-Ghafar Jamshid, Besson Naomi R, Jones Stephanie M, Soong Brian Y, Li Chendi, Vigneau Sebastien, Slyper Michal, Wakiro Isaac, Su Mei-Ju, Helvie Karla, Frangieh Allison, Jane-Valbuena Judit, Ashenberg Orr, Awad Mark, Rotem Asaf, Bueno Raphael, Rozenblatt-Rosen Orit, Pfaff Kathleen, Rodig Scott, Hata Aaron N, Regev Aviv, Johnson Bruce E, Tsankov Alexander M
Abstract excerpt
Tumor protein p53 (TP53) is the most frequently mutated gene across many cancers and is associated with shorter overall survival in lung adenocarcinoma (LUAD). Here, to define how TP53 mutations affect the LUAD tumor microenvironment (TME), we constructed a multiomic cellular and spatial atlas of 23 treatment-naive human lung tumors. We found that TP53-mutant malignant cells lose alveolar identity and upregulate...
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