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Article

Impact of Genomic Mutations on the Transcriptional Pathways and Tumor Microenvironment Landscape of Localized Early Prostate Cancer.

The Prostate - 1 Jul 2026

Lautert-Dutra William, Melo Camila M, Chaves Luiz P, Souza Francisco C, Talebian Vida, Crozier Cheryl, Quintayo Mary Anne, Liao Linda, Dion Dan, Saggioro Fabiano P, Avante Felipe S, Dos Reis Rodolfo B, Squire Jeremy A, Bayani Jane

Abstract excerpt

BACKGROUND: The management of intermediate-risk early prostate cancer (PCa) is challenging due to the difficulty in distinguishing indolent from aggressive tumors. This study explores the association between genomic alterations and the tumor and its microenvironment (TME) and implications for disease progression. METHODS: We performed multi-omic profiling in a cohort of 53 localized PCa using targeted sequencing,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42070269
DOI: 10.1002/pros.70173
PMCID: PMC13270082

Genes

PTEN
RB1
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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