Single-cell Atlas of Penile Cancer Reveals TP53 Mutations as a Driver of an Aggressive Phenotype, Irrespective of Human Papillomavirus Status, and Provides Clues for Treatment Personalization.

doi:10.1016/j.eururo.2024.03.038

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Article

Single-cell Atlas of Penile Cancer Reveals TP53 Mutations as a Driver of an Aggressive Phenotype, Irrespective of Human Papillomavirus Status, and Provides Clues for Treatment Personalization.

European urology - 1 Aug 2024

Elst Laura, Philips Gino, Vandermaesen Kaat, Bassez Ayse, Lodi Francesca, Vreeburg Manon T A, Brouwer Oscar R, Schepers Rogier, Van Brussel Thomas, Mohanty Sambit K, Parwani Anil V, Spans Lien, Vanden Bempt Isabelle, Jacomen Gerd, Baldewijns Marcella, Lambrechts Diether, Albersen Maarten

Abstract excerpt

BACKGROUND AND OBJECTIVE: TP53 loss-of-function (TP53LOF) mutations might be a driver of poor prognosis and chemoresistance in both human papillomavirus (HPV)-independent (HPV-) and HPV-associated (HPV+) penile squamous cell carcinoma (PSCC). Here, we aim to describe transcriptomic differences in the PSCC microenvironment stratified by TP53LOF and HPV status. METHODS: We used single-cell RNA sequencing...

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PMID: 38670879
DOI: 10.1016/j.eururo.2024.03.038

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