Article

Integrated single-cell and spatial transcriptomic analyses unravel the heterogeneity of the prostate tumor microenvironment

2022-04-28

Abstract excerpt

<title>Abstract</title> <p>The treatment of primary prostate cancer delicately balances an active surveillance approach for low-risk disease with multimodal treatment including surgery, radiation therapy, and hormonal therapy for high-risk disease. Recurrence and development of metastatic disease remains a clinical problem, without a clear understanding of what drives immune escape and tumor progression. Here, we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e955ef02-9531-52fe-8bc5-3206bd3f3ed2
DOI: 10.21203/rs.3.rs-1489967/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated single-cell and spatial transcriptomic analyses unravel the heterogeneity of the prostate tumor microenvironmentDOI 10.21203/rs.3.rs-1489967/v1Read

Integrated single-cell and spatial transcriptomic analyses unravel the heterogeneity of the prostate tumor microenvironmentSemantic proximity Read

Spatial whole transcriptome profiling of primary tumor from patients with metastatic prostate cancerSemantic proximity Read

Integrated analysis of single-cell and bulk transcriptomes uncovers clinically relevant molecular subtypes in human prostate cancerSemantic proximity Read

Single-Cell and Spatial Transcriptomic Profiling Reveals Epithelial Functional States and Fibroblast Phenotypes in Hormone Therapy-Naïve Localized Prostate Cancer.Semantic proximity Read

Dissection of prostate tumour, stroma and immune transcriptional components reveals a key contribution of the microenvironment for disease progressionSemantic proximity Read

Deciphering single-cell heterogeneity and cellular ecosystem dynamics during prostate cancer progressionSemantic proximity Read

The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapySemantic proximity Read

Single-cell omics traces the heterogeneity of prostate cancer cells and the tumor microenvironmentSemantic proximity Read

Single cell and spatial transcriptomics highlight the interaction of club-like cells with immunosuppressive myeloid cells in prostate cancerSemantic proximity Read

Distinct mesenchymal cell states mediate prostate cancer progressionSemantic proximity Read

Immunosuppression in the prostate tumor microenvironment is tied to androgen deprivation therapy-resistant club-like cellsSemantic proximity Read

Single-Cell Proteomics Defines the Cellular Heterogeneity of Localized Prostate CancerSemantic proximity Read