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Article

Modulating the Immunosuppressive Tumor Microenvironment and Inhibiting Growth in Mutp53-Driven CRPC via STAT3 Pathway Blockade.

International journal of biological sciences - 1 Jan 2025

Bian Zichen, Chen Jia, Wang Yufan, Jin Chen, Liang Chaozhao, Meng Jialin, Zhang Meng

Abstract excerpt

Mutations in TP53, particularly the p.R248Q variant, contribute to the progression of castration-resistant prostate cancer (CRPC) by reshaping the tumor microenvironment (TME). This study examined the impact of p.R248Q (mutp53) on immune suppression and CRPC progression. We introduced the Trp53 p.R245Q mutation into RM-1 mouse prostate cancer (PCa) cells via CRISPR/Cas9, which mimics human TP53 p.R248Q. These...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40384867
DOI: 10.7150/ijbs.111732
PMCID: PMC12080385

Genes

STAT3
TP53
JAK2
IL6

Variants

Provenance

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