Article

Spatiotemporal profiling reveals the role of inflammatory niche in driving prostate cancer

2026-04-22

Abstract excerpt

Prostate cancer (PCa) is a lethal malignancy that displays profound resistance to immune checkpoint blockade (ICB), via mechanisms that are poorly understood. Here, we investigate the causes of CD8 T cell exhaustion and mechanisms of tumor progression in a PCa animal model, by single cell and spatial profiling, along a time course, following orthotopic transplantation of RB1/TP53/PTEN-deficient mouse organoids, co...

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Literature Corpus work: a1accc40-5bfa-56bc-bd33-5a62d07fd8a1
DOI: 10.64898/2026.04.19.719485

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