Article

High dose-rate brachytherapy of localized prostate cancer converts tumors from cold to hot

2020-03-06

Abstract excerpt

Prostate cancer (PCa) has a profoundly immunosuppressive microenvironment, we hypothesized that radiation therapy would break this immune suppression. To investigate this, we performed high-throughput immune cell subset analysis, and gene expression profiling of pre-versus post-radiation tissue in a cohort of patients with localized disease that received high dose-rate brachytherapy (HDRBT). We resolved tumor and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 751ea5a8-972e-590c-bddc-be0465c54a66
DOI: 10.1101/2020.03.02.20030346

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High dose-rate brachytherapy of localized prostate cancer converts tumors from cold to hotDOI 10.1101/2020.03.02.20030346Read

Integrated single-cell and spatial transcriptomic analyses unravel the heterogeneity of the prostate tumor microenvironmentSemantic proximity Read

The temporal dynamics of the immune response to neoadjuvant androgen deprivation therapy suggests a window-of-opportunity for checkpoint inhibitor therapy in prostate cancerSemantic proximity Read

Integrated single-cell and spatial transcriptomic analyses unravel the heterogeneity of the prostate tumor microenvironmentSemantic proximity Read

Tumor Immune Microenvironment Clusters in Localized Prostate Adenocarcinoma: Prognostic Impact of Macrophage Enriched/Plasma Cell Non-enriched SubtypesSemantic proximity Read

Quantification and molecular correlates of tertiary lymphoid structures in primary prostate cancerSemantic proximity Read

Coordinating single‐cell and bulk RNA ‐seq in deciphering the intratumoral immune landscape and prognostic stratification of prostate cancer patientsSemantic proximity Read

Dissection of prostate tumour, stroma and immune transcriptional components reveals a key contribution of the microenvironment for disease progressionSemantic proximity Read

Resolving the immune landscape of human prostate at a single-cell level in health and cancerSemantic proximity Read

Single-Cell Proteomics Defines the Cellular Heterogeneity of Localized Prostate CancerSemantic proximity Read

Spatial whole transcriptome profiling of primary tumor from patients with metastatic prostate cancerSemantic proximity Read

Identification of Prostate Cancer Subtypes Based on Immune Signature Scores in Bulk and Single Cell TranscriptomesSemantic proximity Read

A Subset of Localized Prostate Cancer Displays an Immunogenic Phenotype Associated with Losses of Key Tumor Suppressor GenesSemantic proximity Read