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Article

Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms.

Nature medicine - 1 Feb 2018

Bezzi Marco, Seitzer Nina, Ishikawa Tomoki, Reschke Markus, Chen Ming, Wang Guocan, Mitchell Caitlin, Ng Christopher, Katon Jesse, Lunardi Andrea, Signoretti Sabina, Clohessy John G, Zhang Jiangwen, Pandolfi Pier Paolo

Abstract excerpt

Multiple immune-cell types can infiltrate tumors and promote progression and metastasis through different mechanisms, including immunosuppression. How distinct genetic alterations in tumors affect the composition of the immune landscape is currently unclear. Here, we characterized the immune-cell composition of prostate cancers driven by the loss of the critical tumor suppressor gene Pten, either alone or in...

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Identifiers

PMID: 29309058
DOI: 10.1038/nm.4463

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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