Article
Ancestry and somatic profile indicate acral melanoma origin and prognosis.
Nature - 1 Mar 2026
Basurto-Lozada Patricia, Vázquez-Cruz Martha Estefania, Molina-Aguilar Christian, Jiang Amanda, Deacon Dekker C, Cerrato-Izaguirre Dennis, Simonin-Wilmer Irving, Arriaga-González Fernanda G, Contreras-Ramírez Kenya L, Ferro-Rodríguez Emiliano, Billington Jamie, Dawson Eric T, Wong-Ramirez J Rene C, Ramos-Galguera Johana Itzel, Álvarez-Cano Alethia, García-Ortega Dorian Y, García-Salinas O Isaac, Hidalgo-Miranda Alfredo, Cisneros-Villanueva Mireya, Johansson Peter A, Martínez-Said Héctor, Gallego-García Pilar, Arends Mark J, Ferreira Ingrid, Tullett Mark, Olvera-León Rebeca, van der Weyden Louise, Del Castillo Velasco-Herrera Martín, Roldán-Marín Rodrigo, Vidaurri de la Cruz Helena, Tavares-de-la-Paz Luis Alberto, Hinojosa-Ugarte Diego, Belote Rachel L, Bishop D Timothy, Díaz-Gay Marcos, Alexandrov Ludmil B, Sánchez-Pérez Yesennia, In Gino K, White Richard M, Possik Patrícia A, Judson-Torres Robert L, Adams David J, Robles-Espinoza Carla Daniela
Abstract excerpt
Acral melanoma, which is not ultraviolet-associated, is the type of melanoma reported most commonly in several non-European-descent populations1-3, including in Mexican people4. Latin American samples are substantially under-represented in global cancer genomics studies5, which directly affects patients in these regions as it is known that cancer risk and incidence may be influenced by ancestry and environmental...
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