Article

Integrative Molecular and Clinical Profiling of Acral Melanoma Identifies LZTR1 as a Key Tumor Promoter and Therapeutic Target

2021-09-30

Abstract excerpt

<title>Abstract</title> <p>Acral melanoma, the most common melanoma subtype among non-Caucasian individuals, is associated with poor prognosis. However, its key molecular drivers remain obscure. Here, we performed integrative genomic and clinical profiling of acral melanomas from a cohort of 104 patients treated in North America or China. We found that recurrent, late-arising amplifications of cytoband chr22q11.2...

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Literature Corpus work: dc6e50cb-3961-5a3d-83ea-fbc4fcac0c13
DOI: 10.21203/rs.3.rs-110475/v1

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