Article
Genomic characterisation of acral melanoma cell lines.
Pigment cell & melanoma research - 1 Jul 2012
Furney Simon J, Turajlic Samra, Fenwick Kerry, Lambros Maryou B, MacKay Alan, Ricken Gerda, Mitsopoulos Costas, Kozarewa Iwanka, Hakas Jarle, Zvelebil Marketa, Lord Christopher J, Ashworth Alan, Reis-Filho Jorge S, Herlyn Meenhard, Murata Hiroshi, Marais Richard
Abstract excerpt
Acral melanoma is a rare melanoma subtype with distinct epidemiological, clinical and genetic features. To determine if acral melanoma cell lines are representative of this melanoma subtype, six lines were analysed by whole-exome sequencing and array comparative genomic hybridisation. We demonstrate that the cell lines display a mutation rate that is comparable to that of published primary and metastatic acral...
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