Article

Integrative molecular and clinical profiling of acral melanoma identifies LZTR1 as a key tumor promoter and therapeutic target

2021-04-21

Abstract excerpt

<h4>ABSTRACT</h4> Acral melanoma, the most common melanoma subtype among non-Caucasian individuals, is associated with poor prognosis. However, its key molecular drivers remain obscure. Here, we performed integrative genomic and clinical profiling of acral melanomas from a cohort of 104 patients treated in North America or China. We found that recurrent, late-arising amplifications of cytoband chr22q11.21 are a l...

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Literature Corpus work: 3d90b490-0dd4-54f8-8abf-5080f479ee83
DOI: 10.1101/2021.04.20.440286

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