Article
Reduced cyclin D3 expression in erythroid cells protects against malaria.
Nature - 1 Mar 2026
Marini Maria Giuseppina, Mingoia Maura, Steri Maristella, Tsamesidis Ioannis, Idda Maria Laura, Manca Alessia, D'Avino Cristina, Virdis Francesca, Lodde Valeria, Mulas Antonella, Asunis Isadora, Li Xinyi, Steiner Margaret C, Loi Angela, Caria Cristian A, Marongiu Maria Franca, Floris Matteo, Marongiu Michele, Manunza Laura, Pitzalis Maristella, Orrù Valeria, Fiorillo Edoardo, Zoledziewska Magdalena, Moi Paolo, Turrini Francesco M, Pala Mauro, Sidore Carlo, Schlessinger David, Novembre John, Pantaleo Antonella, Cucca Francesco
Abstract excerpt
The severity of malaria varies substantially between individuals, but the mechanisms that underlie these differences remain unclear. Because erythrocytes have a key role in malaria biology, genetic variants associated with the development of these cells could inform the mechanisms that determine disease severity. Here we investigate the mechanistic basis of the association of the variant rs112233623-T with...
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