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Article

Environmental Correlation Analysis for Genes Associated with Protection against Malaria.

Molecular biology and evolution - 1 May 2016

Mackinnon Margaret J, Ndila Carolyne, Uyoga Sophie, Macharia Alex, Snow Robert W, Band Gavin, Rautanen Anna, Rockett Kirk A, Kwiatkowski Dominic P, Williams Thomas N

Abstract excerpt

Genome-wide searches for loci involved in human resistance to malaria are currently being conducted on a large scale in Africa using case-control studies. Here, we explore the utility of an alternative approach-"environmental correlation analysis, ECA," which tests for clines in allele frequencies across a gradient of an environmental selection pressure-to identify genes that have historically protected against...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26744416
DOI: 10.1093/molbev/msw004
PMCID: PMC4839215

Genes

CDH13
CTNND2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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