Article

Resistance to malaria through structural variation of red blood cell invasion receptors

2016-10-26

Abstract excerpt

Plasmodium falciparum invades human red blood cells by a series of interactions between host and parasite surface proteins. Here we analyse whole genome sequence data from worldwide human populations, including 765 new genomes from across sub-Saharan Africa, and identify a diverse array of large copy number variants affecting the host invasion receptor genes GYPA and GYPB . We find that a nearby reported associa...

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Identifiers and source

Literature Corpus work: 62e79b30-52d0-5742-916a-747d85965b23
DOI: 10.1101/083634

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