Article

Splenic clearance of rigid erythrocytes as an inherited mechanism for splenomegaly and natural resistance to malaria

2022-03-21

Abstract excerpt

In malaria-endemic areas, subjects from specific groups like Fulani have a peculiar protection against malaria, with high levels of IgM but also frequent anemia and splenomegaly. The mechanisms underlying this phenotype remain elusive. In Benin, West Africa, we measured the deformability of circulating erythrocytes in genetically distinct groups (including Fulani) living in sympatry, using ektacytometry and micros...

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Literature Corpus work: 4a8c59a9-c2ff-553c-b09a-a1669579c368
DOI: 10.1101/2022.03.21.485136

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