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Article

LDAK-GBAT: Fast and powerful gene-based association testing using summary statistics.

American journal of human genetics - 5 Jan 2023

Berrandou Takiy-Eddine, Balding David, Speed Doug

Abstract excerpt

We present LDAK-GBAT, a tool for gene-based association testing using summary statistics from genome-wide association studies that is computationally efficient, produces well-calibrated p values, and is significantly more powerful than existing tools. LDAK-GBAT takes approximately 30 min to analyze imputed data (2.9M common, genic SNPs), requiring less than 10 Gb memory. It shows good control of type 1 error...

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Identifiers

PMID: 36480927
DOI: 10.1016/j.ajhg.2022.11.010
PMCID: PMC9892699

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