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The tissue-specific effects of glucose-lowering drug targets on aging mediated through DNA methylation: a multi-omics genetic study

2025-10-14

Abstract excerpt

<h4>Background</h4> DNA methylation plays a key role in mediating the anti-aging effects of glucose-lowering drugs. This study aims to systematically explore the potential anti-aging effects of target genes of FDA-approved glucose-lowering drugs and the underlying epigenetic mediators. <h4>Method</h4> We conducted a two-sample Mendelian randomization (MR) study to investigate the putative causal relationships be...

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Literature Corpus work
740e87bf-cf10-5fe7-add4-4cf49e803495
DOI
10.1101/2025.10.13.25337858
Open publication

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The tissue-specific effects of glucose-lowering drug targets on aging mediated through DNA methylation: a multi-omics genetic studyDOI 10.1101/2025.10.13.25337858
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