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Article

G2DR: a genotype-first framework for genetics-informed target prioritization and drug repurposing.

Briefings in bioinformatics - 3 Jul 2026

Muneeb Muhammad, Ascher David B

Abstract excerpt

Human genetics offers a scalable route to therapeutic discovery, but practical frameworks that convert genotype-derived signal into ranked target and drug hypotheses remain limited, particularly when matched disease transcriptomics are unavailable. We present G2DR, a genotype-first computational prioritization framework that integrates genetically predicted gene expression, multi-method gene-level testing,...

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PMID: 42574278
DOI: 10.1093/bib/bbag427
PMCID: PMC13455623

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