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The tissue-specific effects of glucose-lowering drug targets on aging mediated through DNA methylation: a multi-omics genetic study

2025-10-21

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> DNA methylation plays a key role in mediating the anti-aging effects of glucose-lowering drugs. This study aims to systematically explore the potential anti-aging effects of target genes of FDA-approved glucose-lowering drugs and the underlying epigenetic mediators. <bold>Methods</bold> We conducted a two-sample Mendelian randomization (MR) study to investig...

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Literature Corpus work
e9701673-1713-566f-bf68-ed62fb17ed24
DOI
10.21203/rs.3.rs-7798894/v1
Open publication

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The tissue-specific effects of glucose-lowering drug targets on aging mediated through DNA methylation: a multi-omics genetic studyDOI 10.21203/rs.3.rs-7798894/v1
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