Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Quantitative trait locus (xQTL) approaches identify risk genes and drug targets from human non-coding genomes.

Human molecular genetics - 20 Oct 2022

Bykova Marina, Hou Yuan, Eng Charis, Cheng Feixiong

Abstract excerpt

Advances and reduction of costs in various sequencing technologies allow for a closer look at variations present in the non-coding regions of the human genome. Correlating non-coding variants with large-scale multi-omic data holds the promise not only of a better understanding of likely causal connections between non-coding DNA and expression of traits but also identifying potential disease-modifying medicines....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Artificial Intelligence
Share to Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Share to Proteomics

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 36018824
DOI: 10.1093/hmg/ddac208
PMCID: PMC9989738

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Quantitative trait locus (xQTL) approaches identify risk genes and drug targets from human non-coding genomes.PMID 36018824Read ↗

Molecular Quantitative Trait Locus Mapping in Human Complex Diseases.Semantic proximity Read ↗

Leveraging molecular quantitative trait loci to comprehend complex diseases/traits from the omics perspective.Semantic proximity Read ↗

Interpreting noncoding genetic variation in complex traits and human disease.Semantic proximity Read ↗

Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer’s diseaseSemantic proximity Read ↗

Expression Quantitative Trait Loci Information Improves Predictive Modeling of Disease Relevance of Non-Coding Genetic Variation.Semantic proximity Read ↗

A systematic approach to understand the functional consequences of non-protein coding risk regions.Semantic proximity Read ↗

Genomic resources for dissecting the role of non-protein coding variation in gene-environment interactions.Semantic proximity Read ↗

Challenges and progress in interpretation of non-coding genetic variants associated with human disease.Semantic proximity Read ↗

Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer's disease.Semantic proximity Read ↗

Leveraging functional annotation to identify genes associated with complex diseases.Semantic proximity Read ↗

SNPnexus: assessing the functional relevance of genetic variation to facilitate the promise of precision medicine.Semantic proximity Read ↗

omicSynth: an Open Multi-omic Community Resource for Identifying Druggable Targets across Neurodegenerative DiseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.