Article

Integration of genetic evidence to identify approved drug targets

2025-10-11

Abstract excerpt

Drugs targeting genes supported by human genetic evidence are more likely to succeed in clinical trials. While previous approaches have benchmarked individual methods such as genome-wide association studies (GWAS), rare variant burden testing, and quantitative trait locus (QTL)-informed Mendelian randomization, it remains unclear how best to integrate these signals for drug target discovery. Here, we compared gene...

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Literature Corpus work: acce9608-286f-5ddf-9e72-e860c16482e2
DOI: 10.1101/2025.10.10.681636

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