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Article

KLF4-PFKFB3-driven glycolysis is essential for phenotypic switching of vascular smooth muscle cells.

Communications biology - 5 Dec 2022

Zhang Xinhua, Zheng Bin, Zhao Lingdan, Shen Jiayi, Yang Zhan, Zhang Yu, Fan Ruirui, Zhang Manli, Ma Dong, Zheng Lemin, Zhao Mingming, Liu Huirong, Wen Jinkun

Abstract excerpt

Vascular smooth muscle cells (VSMCs) within atherosclerotic lesions undergo a phenotypic switching in a KLF4-dependent manner. Glycolysis plays important roles in transdifferentiation of somatic cells, however, it is unclear whether and how KLF4 mediates the link between glycolytic switch and VSMCs phenotypic transitions. Here, we show that KLF4 upregulation accompanies VSMCs phenotypic switching in...

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Identifiers

PMID: 36470917
DOI: 10.1038/s42003-022-04302-y
PMCID: PMC9722670

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