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Article

G6PD maintains the VSMC synthetic phenotype and accelerates vascular neointimal hyperplasia by inhibiting the VDAC1-Bax-mediated mitochondrial apoptosis pathway.

Cellular & molecular biology letters - 8 Apr 2024

Zhang Ting, Cao Rui-Jie, Niu Jiang-Ling, Chen Zhi-Huan, Mu Shi-Qing, Cao Tong, Pang Jie-Xin, Dong Li-Hua

Abstract excerpt

BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) plays an important role in vascular smooth muscle cell (VSMC) phenotypic switching, which is an early pathogenic event in various vascular remodeling diseases (VRDs). However, the underlying mechanism is not fully understood. METHODS: An IP‒LC‒MS/MS assay was conducted to identify new binding partners of G6PD involved in the regulation of VSMC phenotypic...

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Identifiers

PMID: 38589823
DOI: 10.1186/s11658-024-00566-w
PMCID: PMC11003121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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