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Article

KDM5C and KDM5D influence DNA methylation in adult mouse liver.

Biology of sex differences - 12 Feb 2026

Gibbons Emily, Oros Klein Kathleen, Inoue Shinya, Kimura Tohru, Greenwood Celia M T, Naumova Anna K

Abstract excerpt

BACKGROUND: Several lines of evidence suggest that the sex-chromosome complement influences autosomal gene regulation and DNA methylation, however, the exact molecular mechanisms responsible for such effects remain elusive. X-linked epigenetic modifiers that escape X-chromosome inactivation, and hence have higher dosage in female cells, are the primary gene candidates for mediating the effects of X-dosage,...

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Topics

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Share to DNA Methylation
Share to Histone Demethylases
Share to Liver

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

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Source

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Identifiers

PMID: 41680953
DOI: 10.1186/s13293-026-00844-6
PMCID: PMC13011546

Genes

KDM5C
KDM5D

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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