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Article

Intergenerational epigenetic inheritance of cancer susceptibility in mammals

8 Apr 2019

Abstract excerpt

Susceptibility to cancer is heritable, but much of this heritability remains unexplained. Some ‘missing’ heritability may be mediated by epigenetic changes in the parental germ line that do not involve transmission of genetic variants from parent to offspring. We report that deletion of the chromatin regulator Kdm6a (Utx) in the paternal germ line results in elevated tumor incidence in genetically wild type mice....

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PMID: 30963999
DOI: 10.7554/elife.39380

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