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Article

X chromosome protects against bladder cancer in females via a KDM6A-dependent epigenetic mechanism.

Science advances - 1 Jun 2018

Kaneko Satoshi, Li Xue

Abstract excerpt

Men are much more likely than women to develop bladder cancer (BCa), but the underlying cause of this gender disparity remains poorly defined. Using sex-reversed mice, we show that the sex chromosome complement is an independent cause and, moreover, amplifies the biasing effects of sex hormones. We also show that the X-linked lysine demethylase 6A (KDM6A) is a sexually dimorphic gene. Wild-type but not...

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Share to Cyclin-Dependent Kinase Inhibitor p21
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29928692
DOI: 10.1126/sciadv.aar5598
PMCID: PMC6007159

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