Article

KDM5C is a sex-biased brake against germline gene expression programs in somatic lineages

2024-11-08

Abstract excerpt

The division of labor among cellular lineages is a pivotal step in the evolution of multicellularity. In mammals, the soma-germline boundary is formed during early embryogenesis, when genes that drive germline identity are repressed in somatic lineages through DNA and histone modifications at promoter CpG islands (CGIs). Somatic misexpression of germline genes is a signature of cancer and observed in select neurod...

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Literature Corpus work: d0840fcf-2e7e-5e29-abdf-b8027da37ecb
DOI: 10.1101/2024.11.08.622665

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