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Article

Wnt-dependent modulation of alveolar epithelial phenotypes and barrier function in human progenitor-like cells.

Biochemical and biophysical research communications - 2 Apr 2026

Lin Yu-Che, Igarashi Miki, Sakai Yasuyuki, Nishikawa Masaki, Ishikawa Shinkichi, Tanabe Ikuya

Abstract excerpt

Alveolar regeneration requires coordinated alveolar type 1 (AT1)/alveolar type 2 (AT2) responses and an intact epithelial barrier. In vitro systems, however, rarely couple lineage control with high resistance. Here we establish a concise workflow in which human AT2-like progenitors are expanded in a medium containing a small-molecule cocktail (Y-27632/A-83-01/CHIR99021; YAC), followed by air-liquid interface...

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Source

Identifiers

PMID: 41678947
DOI: 10.1016/j.bbrc.2026.153384

Genes

AGER
AQP5
PDPN
SFTPB
SFTPC
SFTPD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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