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Screening of factors inducing alveolar type 1 epithelial cells using human pluripotent stem cells

28 Mar 2024

Abstract excerpt

Alveolar type 2 (AT2) epithelial cells are tissue stem cells capable of differentiating into alveolar type 1 (AT1) cells for injury repair and maintenance of lung homeostasis. However, the factors involved in human AT2-to-AT1 cell differentiation are not fully understood. Here, we established SFTPC GFP and AGER mCherry-HiBiT dual-reporter induced pluripotent stem cells (iPSCs), which detected AT2-to-AT1 cell...

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PMID: 38552636
DOI: 10.1016/j.stemcr.2024.02.009

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