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Article

Functional human iPSC-derived alveolar-like cells cultured in a miniaturized 96‑Transwell air-liquid interface model.

Scientific reports - 23 Aug 2021

Bluhmki Teresa, Traub Stefanie, Müller Ann-Kathrin, Bitzer Sarah, Schruf Eva, Bammert Marie-Therese, Leist Marcel, Gantner Florian, Garnett James P, Heilker Ralf

Abstract excerpt

In order to circumvent the limited access and donor variability of human primary alveolar cells, directed differentiation of human pluripotent stem cells (hiPSCs) into alveolar-like cells, provides a promising tool for respiratory disease modeling and drug discovery assays. In this work, a unique, miniaturized 96-Transwell microplate system is described where hiPSC-derived alveolar-like cells were cultured at an...

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Identifiers

PMID: 34426605
DOI: 10.1038/s41598-021-96565-4
PMCID: PMC8382767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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